ANKRD11
Downstream-CDS high-coverage with context burden
| MANE transcript | ENST00000301030.10 |
|---|---|
| ClinVar P/LP records | 652 |
| Low-record-burden flag | no |
| Unit rows | 67 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 85.3% | 6,578 bp |
| Adjacent exon block | 93.4% | 7,062 bp |
| Downstream-CDS | 100.0% | 7,989 bp |
Why this classification?
- Downstream coverage is high, but boundary, splice, dosage, or context assumptions dominate interpretation.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| KBG syndrome | 423 | Boundary-CDS payload architecture | 0.926714 | 0.992908 |
| Inborn genetic diseases | 75 | Boundary-CDS payload architecture | 0.960000 | 1.000000 |
| ANKRD11-related disorder | 26 | Boundary-CDS payload architecture | 1.000000 | 1.000000 |