APC
Tumor-predisposition control/caution
| MANE transcript | ENST00000257430.9 |
|---|---|
| ClinVar P/LP records | 2556 |
| Low-record-burden flag | no |
| Unit rows | 85 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 63.8% | 8,687 bp |
| Adjacent exon block | 75.5% | 9,237 bp |
| Downstream-CDS | 99.6% | 8,529 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Familial adenomatous polyposis 1 | 2,057 | Tumor-predisposition control context | 0.747205 | 0.991736 |
| Hereditary cancer-predisposing syndrome | 1,035 | Tumor-predisposition control context | 0.737198 | 0.991304 |
| Familial multiple polyposis syndrome | 150 | Tumor-predisposition control context | 0.666667 | 0.986667 |
| Carcinoma of colon | 97 | Tumor-predisposition control context | 0.618557 | 0.938144 |
| Classic or attenuated familial adenomatous polyposis | 66 | Tumor-predisposition control context | 0.727273 | 0.939394 |
| Desmoid disease, hereditary | 43 | Tumor-predisposition control context | 0.488372 | 0.953488 |
| Gastric cancer | 40 | Tumor-predisposition control context | 0.600000 | 1.000000 |
| Colorectal cancer | 40 | Tumor-predisposition control context | 0.550000 | 1.000000 |