ATM
Tumor-predisposition control/caution
| MANE transcript | ENST00000675843.1 |
|---|---|
| ClinVar P/LP records | 3732 |
| Low-record-burden flag | no |
| Unit rows | 367 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 3.4% | 372 bp |
| Adjacent exon block | 11.7% | 1,140 bp |
| Downstream-CDS | 100.0% | 9,168 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Ataxia-telangiectasia syndrome | 2,437 | Tumor-predisposition control context | 0.121461 | 0.991383 |
| Hereditary cancer-predisposing syndrome | 1,908 | Tumor-predisposition control context | 0.119497 | 0.997904 |
| Familial cancer of breast | 1,824 | Tumor-predisposition control context | 0.124452 | 0.999452 |
| ATM-related cancer predisposition | 126 | Tumor-predisposition control context | 0.150794 | 0.976190 |
| Gastric cancer | 80 | Tumor-predisposition control context | 0.137500 | 1.000000 |
| Malignant tumor of breast | 63 | Tumor-predisposition control context | 0.158730 | 0.968254 |
| ATM-related disorder | 58 | Tumor-predisposition control context | 0.155172 | 1.000000 |
| Breast and/or ovarian cancer | 39 | Tumor-predisposition control context | 0.205128 | 1.000000 |