BRIP1
Tumor-predisposition control/caution
| MANE transcript | ENST00000259008.7 |
|---|---|
| ClinVar P/LP records | 875 |
| Low-record-burden flag | no |
| Unit rows | 109 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 8.9% | 291 bp |
| Adjacent exon block | 32.7% | 961 bp |
| Downstream-CDS | 100.0% | 3,747 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Familial cancer of breast | 723 | Tumor-predisposition control context | 0.320885 | 0.991701 |
| Fanconi anemia complementation group J | 507 | Tumor-predisposition control context | 0.323471 | 0.990138 |
| Hereditary cancer-predisposing syndrome | 424 | Tumor-predisposition control context | 0.323113 | 1.000000 |
| Ovarian cancer | 45 | Tumor-predisposition control context | 0.355556 | 1.000000 |
| Hereditary breast ovarian cancer syndrome | 32 | Tumor-predisposition control context | 0.406250 | 1.000000 |
| Familial ovarian cancer | 28 | Tumor-predisposition control context | 0.571429 | 1.000000 |
| Gastric cancer | 24 | Tumor-predisposition control context | 0.375000 | 1.000000 |