CDH1
Tumor-predisposition control/caution
| MANE transcript | ENST00000261769.10 |
|---|---|
| ClinVar P/LP records | 622 |
| Low-record-burden flag | no |
| Unit rows | 85 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 10.6% | 245 bp |
| Adjacent exon block | 37.1% | 1,027 bp |
| Downstream-CDS | 97.1% | 2,598 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Hereditary diffuse gastric adenocarcinoma | 495 | Tumor-predisposition control context | 0.379798 | 0.945455 |
| Hereditary cancer-predisposing syndrome | 263 | Tumor-predisposition control context | 0.368821 | 0.961977 |
| CDH1-related diffuse gastric and lobular breast cancer syndrome | 160 | Tumor-predisposition control context | 0.375000 | 0.943750 |
| Familial cancer of breast | 59 | Tumor-predisposition control context | 0.389831 | 0.949153 |