DICER1
Tumor-predisposition control/caution
| MANE transcript | ENST00000343455.8 |
|---|---|
| ClinVar P/LP records | 833 |
| Low-record-burden flag | no |
| Unit rows | 151 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 16.1% | 781 bp |
| Adjacent exon block | 45.7% | 2,258 bp |
| Downstream-CDS | 100.0% | 5,766 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| DICER1-related tumor predisposition | 644 | Tumor-predisposition control context | 0.473602 | 0.992236 |
| Hereditary cancer-predisposing syndrome | 286 | Tumor-predisposition control context | 0.458042 | 1.000000 |
| Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome | 36 | Tumor-predisposition control context | 0.444444 | 1.000000 |
| Pleuropulmonary blastoma | 32 | Tumor-predisposition control context | 0.406250 | 1.000000 |
| Euthyroid goiter | 23 | Tumor-predisposition control context | 0.347826 | 1.000000 |