FLG
Downstream-CDS high-coverage with context burden
| MANE transcript | ENST00000368799.2 |
|---|---|
| ClinVar P/LP records | 246 |
| Low-record-burden flag | no |
| Unit rows | 8 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 98.0% | 12,583 bp |
| Adjacent exon block | 100.0% | 12,742 bp |
| Downstream-CDS | 100.0% | 12,183 bp |
Why this classification?
- Downstream coverage is high, but boundary, splice, dosage, or context assumptions dominate interpretation.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Ichthyosis vulgaris | 103 | Boundary-CDS payload architecture | 1.000000 | 1.000000 |
| Dermatitis, atopic, 2 | 41 | Boundary-CDS payload architecture | 1.000000 | 1.000000 |