FLNC
Downstream-CDS high-coverage with context burden
| MANE transcript | ENST00000325888.13 |
|---|---|
| ClinVar P/LP records | 606 |
| Low-record-burden flag | no |
| Unit rows | 277 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 4.6% | 270 bp |
| Adjacent exon block | 15.7% | 1,316 bp |
| Downstream-CDS | 96.5% | 7,823 bp |
Why this classification?
- Downstream coverage is high, but boundary, splice, dosage, or context assumptions dominate interpretation.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Hypertrophic cardiomyopathy 26 | 490 | Boundary-CDS payload architecture | 0.163265 | 0.955102 |
| Myofibrillar myopathy 5 | 455 | Boundary-CDS payload architecture | 0.151648 | 0.953846 |
| Distal myopathy with posterior leg and anterior hand involvement | 455 | Boundary-CDS payload architecture | 0.151648 | 0.953846 |
| Cardiovascular phenotype | 117 | Boundary-CDS payload architecture | 0.222222 | 0.974359 |
| Primary familial dilated cardiomyopathy | 21 | Boundary-CDS payload architecture | 0.190476 | 1.000000 |