GLA
Compact downstream-CDS record-coverage hypothesis
| MANE transcript | ENST00000218516.4 |
|---|---|
| ClinVar P/LP records | 1115 |
| Low-record-burden flag | no |
| Unit rows | 31 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 18.8% | 297 bp |
| Adjacent exon block | 72.4% | 927 bp |
| Downstream-CDS | 85.4% | 1,093 bp |
Why this classification?
- Downstream-CDS record coverage is 85.4% with an estimated payload of 1,093 bp (≤5 kb).
- This label is boundary-based: high coverage can occur when many coding records lie downstream of an early transcript boundary.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Fabry disease | 1,089 | Local compact architecture | 0.724518 | 0.841139 |
| Cardiovascular phenotype | 55 | Boundary-CDS payload architecture | 0.709091 | 0.854545 |
| Migalastat response | 22 | Diffuse/moderate architecture | 0.772727 | 0.727273 |