MSH6
Tumor-predisposition control/caution
| MANE transcript | ENST00000234420.11 |
|---|---|
| ClinVar P/LP records | 2246 |
| Low-record-burden flag | no |
| Unit rows | 49 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 52.7% | 2,545 bp |
| Adjacent exon block | 75.8% | 3,174 bp |
| Downstream-CDS | 96.1% | 3,820 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Hereditary cancer-predisposing syndrome | 1,324 | Tumor-predisposition control context | 0.785498 | 0.954683 |
| Lynch syndrome 5 | 1,114 | Tumor-predisposition control context | 0.777379 | 0.961400 |
| Hereditary nonpolyposis colorectal neoplasms | 1,072 | Tumor-predisposition control context | 0.768657 | 0.961754 |
| Lynch syndrome | 330 | Tumor-predisposition control context | 0.824242 | 0.975758 |
| Endometrial carcinoma | 278 | Tumor-predisposition control context | 0.791367 | 0.964029 |
| Hereditary nonpolyposis colon cancer | 131 | Tumor-predisposition control context | 0.870229 | 1.000000 |
| Mismatch repair cancer syndrome 3 | 71 | Tumor-predisposition control context | 0.774648 | 0.943662 |
| Carcinoma of colon | 53 | Tumor-predisposition control context | 0.698113 | 0.943396 |