PALB2
Tumor-predisposition control/caution
| MANE transcript | ENST00000261584.9 |
|---|---|
| ClinVar P/LP records | 1420 |
| Low-record-burden flag | no |
| Unit rows | 67 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 40.0% | 1,473 bp |
| Adjacent exon block | 70.5% | 2,623 bp |
| Downstream-CDS | 98.1% | 3,510 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Familial cancer of breast | 1,172 | Tumor-predisposition control context | 0.711604 | 0.971843 |
| Hereditary cancer-predisposing syndrome | 779 | Tumor-predisposition control context | 0.712452 | 0.967908 |
| Breast-ovarian cancer, familial, susceptibility to, 5 | 95 | Tumor-predisposition control context | 0.610526 | 0.978947 |
| Hereditary breast ovarian cancer syndrome | 93 | Tumor-predisposition control context | 0.655914 | 0.967742 |
| Pancreatic cancer, susceptibility to, 3 | 76 | Tumor-predisposition control context | 0.526316 | 0.973684 |
| Fanconi anemia complementation group N | 75 | Tumor-predisposition control context | 0.506667 | 0.986667 |
| Malignant tumor of breast | 47 | Tumor-predisposition control context | 0.702128 | 0.978723 |
| PALB2-related disorder | 43 | Tumor-predisposition control context | 0.674419 | 1.000000 |