SDHA
Tumor-predisposition control/caution
| MANE transcript | ENST00000264932.11 |
|---|---|
| ClinVar P/LP records | 320 |
| Low-record-burden flag | no |
| Unit rows | 79 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 10.9% | 169 bp |
| Adjacent exon block | 39.7% | 768 bp |
| Downstream-CDS | 93.1% | 1,929 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Pheochromocytoma/paraganglioma syndrome 5 | 250 | Tumor-predisposition control context | 0.400000 | 0.904000 |
| Mitochondrial complex II deficiency, nuclear type 1 | 216 | Tumor-predisposition control context | 0.407407 | 0.921296 |
| Hereditary cancer-predisposing syndrome | 170 | Tumor-predisposition control context | 0.388235 | 0.900000 |
| Dilated cardiomyopathy 1GG | 47 | Tumor-predisposition control context | 0.510638 | 0.957447 |
| Neurodegeneration with ataxia and late-onset optic atrophy | 21 | Tumor-predisposition control context | 0.476190 | 0.857143 |