SDHB
Tumor-predisposition control/caution
| MANE transcript | ENST00000375499.8 |
|---|---|
| ClinVar P/LP records | 280 |
| Low-record-burden flag | no |
| Unit rows | 37 |
Unit-level record coverage
| Unit type | Best record coverage | Estimated payload |
|---|---|---|
| Single exon | 18.6% | 123 bp |
| Adjacent exon block | 73.2% | 565 bp |
| Downstream-CDS | 93.6% | 768 bp |
Why this classification?
- This gene is retained as a control/caution class because high ClinVar burden should not be read as replacement suitability.
How to read this page
Record coverage summarizes ClinVar P/LP records mapped to this gene. It does not estimate patient coverage, editing efficiency, therapeutic efficacy, or safety.
Downstream-CDS values are transcript-boundary hypotheses. High downstream coverage can be boundary-driven and should be read with payload and context burden.
Condition-associated pathogenic-record groups
Record-level ClinVar condition facets. These are not patient cohorts, disease prevalence, or patient coverage.
| Condition label | P/LP records | Condition architecture | Local coverage | Boundary-CDS coverage |
|---|---|---|---|---|
| Pheochromocytoma/paraganglioma syndrome 4 | 218 | Tumor-predisposition control context | 0.729358 | 0.903670 |
| Pheochromocytoma | 204 | Tumor-predisposition control context | 0.730392 | 0.911765 |
| Gastrointestinal stromal tumor | 203 | Tumor-predisposition control context | 0.733990 | 0.911330 |
| Hereditary cancer-predisposing syndrome | 148 | Tumor-predisposition control context | 0.750000 | 0.905405 |
| Hereditary pheochromocytoma and paraganglioma | 79 | Tumor-predisposition control context | 0.822785 | 0.924051 |