Opportunity units
Single exon
5' ─ E1 ─ [E2] ─ E3 ─ 3'
Coverage asks what fraction of gene-level ClinVar P/LP records falls in one exon.
Adjacent exon block
5' ─ E1 ─ [E2 ─ E3 ─ E4] ─ E5 ─ 3'
Coverage asks what fraction falls in a local block of neighboring exons.
Downstream-CDS
5' ─ E1 | [downstream coding payload] ─ 3'
boundary
Coverage asks what fraction lies downstream of a transcript boundary. Early boundaries can make coverage high, so read this with donor payload and context caveats.
Payload bins
| Bin | Meaning |
|---|---|
| ≤5 kb | compact payload descriptor |
| 5–20 kb | moderate payload burden |
| >20 kb | large-payload / donor/payload-burden caveat |
| >50 kb | ultra-large burden |
Payload bins are interpretation bins, not feasibility cutoffs.