PrimeReplace Atlas Browser
PrimeReplace Atlas maps ClinVar pathogenic/likely pathogenic records onto MANE/GENCODE transcript structures to show how disease-associated variant burden is distributed across exons, exon blocks, and coding-payload units.
The atlas supports pre-implementation target-architecture review for large-fragment genome-writing hypotheses. It reports record support, transcript-unit type, record-level coverage, payload/context burden, architecture labels, and condition-associated record facets.
Atlas workflow schematic
Overview schematic for the PrimeReplace Atlas workflow.
Search a gene
Open a gene page and read its architecture label, record coverage, payload summary, and interpretation limits.
Start with a guided route
Move from a gene query to architecture labels, unit coverage, condition facets, and source tables.
Review condition facets
Inspect ClinVar condition-associated record groups where condition-level architecture summaries are available.
Download release tables
Use release tables to trace gene-level summaries, condition-associated records, and validation outputs.
How to read the atlas
Record coverage is the fraction of ClinVar P/LP records mapped to a gene or condition-associated record group. It is not patient coverage.
Architecture labels summarize record organization across transcript units. They are not editing-efficiency, safety, clinical-efficacy, or final implementation-mode predictions.
PrimeReplace Atlas Browser release 1.0.1.